|
rs7096206
|
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs1946518
|
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs7975232
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs699947
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs3025039
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs2228570
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Collectively, this meta-analysis proved that VDR rs7975232, VDR rs2228570, VEGF rs699947, VEGF rs3025039, IL-18 rs1946518, and MBL rs7096206 polymorphisms may confer susceptibility to HCC in certain populations.
|
31830994 |
2019 |
|
rs12979860
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
IL28B rs12979860 polymorphism was significantly associated with HCC development after DAAs.
|
31826071 |
2019 |
|
rs2132039
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
A univariate-multivariate analysis showed that viral etiology (chronic hepatitis B, C) and the UDP glucuronosyltransferase family 2 member B28 (UGT2B28) genomic variant rs2132039 were independently associated with the age at presentation of HCC (all adjusted P < 0.05).
|
31805979 |
2019 |
|
rs34000982
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data suggest that the rs34000982 polymorphism may contribute to HCC susceptibility, in full or at least partially through the effect on HMGB1 transcriptional activity by disturbing the binding of miR-636 with the 3'UTR of HMGB1.
|
31777261 |
2020 |
|
rs920778
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma.
|
31759985 |
2020 |
|
rs3746444
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was significant difference in miR-499 (rs3746444) genotypes frequency between the three studied groups as the GG genotype was significantly lower in HCC cases than other groups (P = 0.009) while the combined miR-499 (AA+AG) genotypes were significantly higher in HCC cases than other groups (P = 0.005).
|
31759375 |
2019 |
|
rs11614913
|
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-196a2 (rs11614913) C>T polymorphisms, no significant association was found with HCC risk.
|
31759375 |
2019 |
|
rs2844512
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs2844512 G > C variant in LINC01149 was identified to facilitate HBV spontaneous recovery (OR = 0.84, 95% CI = 0.77-0.92) but increase the risk of HCC (OR = 1.21, 95% CI = 1.11-1.32) in combined samples.
|
31754211 |
2020 |
|
rs58542926
|
|
Liver carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis.
|
31752753 |
2019 |
|
rs28934571
|
|
Liver carcinoma
|
|
0.800 |
GeneticVariation
|
BEFREE |
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells.
|
31747859 |
2020 |
|
rs1695
|
|
Liver carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Herein, we investigated the relationship of three GSTs polymorphisms (GSTT1 deletion, GSTM1 deletion, GSTP1 rs1695) as well as GSTP1 promoter region DNA methylation and HCC risk with a particular focus on the interaction with OCPs exposure among 90 HCC cases and 99 controls in a Chinese population.
|
31731000 |
2020 |
|
rs6568431
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, through this study it is revealed for the first time that rs6568431 may be associated with susceptibility to HBV infection and that rs548234 may be associated with HCC risk in chronic HBV infection, supporting the presence of HBV-related disease-causing regulatory polymorphisms in the PRDM1-ATG5 intergenic region.
|
31729038 |
2019 |
|
rs548234
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, through this study it is revealed for the first time that rs6568431 may be associated with susceptibility to HBV infection and that rs548234 may be associated with HCC risk in chronic HBV infection, supporting the presence of HBV-related disease-causing regulatory polymorphisms in the PRDM1-ATG5 intergenic region.
|
31729038 |
2019 |
|
rs1801133
|
|
Liver carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population.
|
31694048 |
2019 |
|
rs9651118
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population.
|
31694048 |
2019 |
|
rs3753584
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In summary, our findings suggested that MTHFR rs3753584, rs9651118 and rs1801133 polymorphisms may affect the risk of HCC in Chinese Han population.
|
31694048 |
2019 |
|
rs7975232
|
|
Liver carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis.
|
31682785 |
2020 |
|
rs538321148
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that six SNPs in ADAMTS4 were differential distribution between cases and controls via the primary screening analyses; however, only rs538321148 and rs1014509103 polymorphisms were further identified to modify the risk of HCC (odds ratio: 2.73 and 2.95; 95% confidence interval, 2.28-3.29 and 2.43-3.58; P-value, 5.73 × 10<sup>-27</sup> and 1.36 × 10<sup>-27</sup> , respectively).
|
31663692 |
2019 |
|
rs1014509103
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that six SNPs in ADAMTS4 were differential distribution between cases and controls via the primary screening analyses; however, only rs538321148 and rs1014509103 polymorphisms were further identified to modify the risk of HCC (odds ratio: 2.73 and 2.95; 95% confidence interval, 2.28-3.29 and 2.43-3.58; P-value, 5.73 × 10<sup>-27</sup> and 1.36 × 10<sup>-27</sup> , respectively).
|
31663692 |
2019 |
|
rs780829437
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two significant mutations - K10Q and R70Q - were observed in genotype 5a sequences and have been associated with increased risk of hepatocellular carcinoma (HCC), while R70Q confers resistance to interferon-based treatments.
|
31640596 |
2019 |